Key result
Creation of an arteriovenous fistula in stage-5 CKD patients significantly reduced carotido-femoral pulse wave velocity from 13.2 to 11.7 m/s (P<0.001), indicating improved aortic stiffness.
Why the study?
Does the creation of arteriovenous fistulas improve aortic stiffness in patients with stage-5 chronic kidney disease?
Population
31 patients with stage-5 chronic kidney disease (CKD)
Comparison
Creation of arteriovenous fistulas (AVF) vs Pre-AVF baseline (within-subject comparison)
Design
Cohort
Follow-up
3 months
Authors
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Hypothesis-generating for AVF vascular effects in stage-5 CKD; should not yet change practice.
Observational (n=31)
Does the creation of arteriovenous fistulas improve aortic stiffness in patients with stage-5 chronic kidney disease?
Absolute Event Rate: 11.7% vs 13.2%
p-value: p=<0.001
Creation of an arteriovenous fistula in stage-5 CKD patients is associated with a passive improvement in aortic stiffness, particularly in those with stiffer arteries at baseline.
Utescu et al. (2009) conducted an observational in Stage-5 chronic kidney disease (n=31). Creation of arteriovenous fistulas (AVF) vs. Pre-AVF baseline was evaluated on Carotido-femoral pulse wave velocity ((c-f)PWV) (p=<0.001). Creation of an arteriovenous fistula in stage-5 CKD patients significantly reduced carotido-femoral pulse wave velocity from 13.2 to 11.7 m/s (P<0.001), indicating improved aortic stiffness.
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