Key result
Diabetes status could not be evaluated for differences in arterial stiffness or arteriovenous fistula morphology.
Why the study?
It was unclear whether diabetes mellitus adds stiffness to the central arteries or affects the peripheral arteriovenous fistula of hemodialysis patients.
Does diabetes mellitus increase central or peripheral arterial stiffness and alter radiocephalic arteriovenous fistula morphology and flow compared to non-diabetic status in maintenance hemodialysis patients?
Does diabetes mellitus increase central or peripheral arterial stiffness and alter radiocephalic arteriovenous fistula morphology and flow compared to non-diabetic status in maintenance hemodialysis patients?
In maintenance hemodialysis patients, diabetes mellitus is associated with a smaller radiocephalic arteriovenous fistula diameter, though it does not significantly alter central or peripheral arterial stiffness, renal resistive index, or fistula volume flow.
Smaller AVF diameter in diabetes may warrant monitoring; leaves open prospective effects on fistula maturation.
Background: Diabetes mellitus accelerates cardiovascular deterioration in chronic kidney disease, but it is unclear whether it adds stiffness to the central arteries or affects the peripheral arteriovenous fistula (AVF) of hemodialysis patients. Objective: To compare central and peripheral pulse wave velocity (cfPWV, faPWV), renal resistive index (RI), and radiocephalic AVF diameter and volume flow between diabetic and non-diabetic hemodialysis patients. Methods: This analytical cross-sectional study included 120 prevalent hemodialysis patients (22 diabetic, 98 non-diabetic) at Dr. M. Djamil General Hospital in 2025. One blinded sonographer measured the vascular parameters by Doppler ultrasonography. Groups were compared with t-tests and chi-square tests, with 95% confidence intervals and Cohen's d. Results: Diabetic patients were older (56.4 ± 8.1 vs. 50.6 ± 9.4 years; p = 0.004) and had lower diastolic blood pressure (73.27 ± 9.84 vs. 79.72 ± 10.15 mmHg; p = 0.008). cfPWV (2.89 ± 0.57 vs. 2.90 ± 0.61 m/s; p = 0.941), faPWV (3.34 ± 0.73 vs. 3.15 ± 0.69 m/s; p = 0.236), and mean RI (0.825 ± 0.029 vs. 0.818 ± 0.033; p = 0.341) did not differ. AVF diameter was smaller in diabetic patients (1.74 ± 0.63 vs. 2.36 ± 0.74 mm; p < 0.001; Cohen's d = −0.86), whereas flow did not differ significantly (3489 ± 1018 vs. 3063 ± 945 mL/min; p = 0.072). Conclusion: Diabetes was associated with a smaller AVF diameter but not with higher central or peripheral stiffness or renal RI. Given the cross-sectional, unadjusted design, adjusted longitudinal studies are needed.
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Harun et al. (2026) studied Maintenance hemodialysis. Diabetes mellitus vs. Non-diabetic patients was evaluated on Arterial stiffness and radiocephalic arteriovenous fistula morphology. Diabetes versus non-diabetes comparisons of arterial stiffness and radiocephalic fistula morphology could not be determined because the provided text is an Indonesian journal accreditation decree.
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