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October 31, 2008American Journal of Nephrology

Comparison of Ankle-Brachial Index and Brachial-Ankle Pulse Wave Velocity between Patients with Chronic Kidney Disease and Hemodialysis

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Key result

Hemodialysis was associated with a higher prevalence of peripheral artery occlusive disease (ABI <0.9) compared to CKD stage 3-5 (15.6% vs. 8.3%, p=0.030), while arterial stiffness was comparable.

Why the study?

Is there a difference in ankle-brachial index and brachial-ankle pulse wave velocity between patients on hemodialysis and those with CKD stage 3-5?

Population

394 patients, comprising 169 with chronic kidney disease stage 3-5 and 225 on hemodialysis, from one…

Comparison

Hemodialysis vs Chronic kidney disease (CKD) stage 3-5

Design

Cross-sectional

Authors

SCSzu‐Chia ChenNational Yang Ming Chiao Tung UniversityJCJer‐Ming ChangUniversity of the West Indies SystemSHShang‐Jyh HwangInje University

Discussion

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Member takes

Implication

May support targeted PAOD screening in hemodialysis; leaves open causal direction and outcome impact.

Study Design

Type

Cross-Sectional (n=394)

Multicenter

No

Structured PICO

Is there a difference in ankle-brachial index and brachial-ankle pulse wave velocity between patients on hemodialysis and those with CKD stage 3-5?

P
Population
394 patients (169 with CKD stage 3-5 and 225 on hemodialysis) evaluated for peripheral artery occlusive disease and arterial stiffness at a single regional hospital.
E
Exposure
Hemodialysis
C
Comparator
Chronic kidney disease (CKD) stage 3-5
O
Outcome
Ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV)surrogate

Main Result

Absolute Event Rate: 15.6% vs 8.3%

p-value: p=0.030

Peripheral artery occlusive disease (indicated by ABI <0.9) is more prevalent in hemodialysis patients than in those with CKD stage 3-5, whereas arterial stiffness is comparable.

Cite This Study

Chen et al. (2008) conducted a cross-sectional in Chronic kidney disease and hemodialysis (n=394). Hemodialysis vs. CKD stage 3-5 was evaluated on Prevalence of ankle-brachial index (ABI) <0.9 (p=0.030). Hemodialysis was associated with a higher prevalence of peripheral artery occlusive disease (ABI <0.9) compared to CKD stage 3-5 (15.6% vs. 8.3%, p=0.030), while arterial stiffness was comparable.

synapsesocial.com/papers/6a896ca91eb172474f3e7bc3https://doi.org/10.1159/000168485
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Determinants of Arterial Wall Stiffness and Peripheral Artery Occlusive Disease in Nondiabetic Hemodialysis Patients2007 · 36 citations
  2. 2Pulse Wave Velocity in Lower-Limb Arteries among Diabetic Patients with Peripheral Arterial Disease.2003 · 131 citations
  3. 3An Association between Decreased Estimated Glomerular Filtration Rate and Arterial Stiffness2008 · 56 citations
  4. 4Aortic Stiffness Is an Independent Predictor of Primary Coronary Events in Hypertensive Patients2002 · 1,751 citations
  5. 5Assessment of peripheral vascular disease in diabetes. Report and recommendations of an International Workshop sponsored by the American Heart Association and the American Diabetes Association 18-20 September 1992, New Orleans, Louisiana1993 · 111 citations