Key result
A rare case of primary gastric synovial sarcoma was identified in a 13-year-old male child, highlighting the need to consider it in the differential diagnosis of gastric spindle cell neoplasms.
Why the study?
Synovial sarcoma most commonly arises in soft tissues of the extremity, and involvement of the gastrointestinal tract is very rare.
Case Report (n=1)
Highlights the need to include synovial sarcoma in the differential diagnosis of spindle cell neoplasms in the stomach.
Supports including synovial sarcoma in the differential for pediatric gastric spindle cell tumors; leaves open multicenter data on outcomes.
Synovial sarcoma is a mesenchymal neoplasm that shows a specific t(X;18) translocation that leads to the formation of SS18-SSX gene fusions and is most commonly seen in soft tissues of the extremity. The gastrointestinal tract is a very rare site of involvement. We report a case of primary gastric synovial sarcoma in a 13-year-old male child. Synovial sarcoma should be included in the differential diagnosis when spindle cell neoplasms are encountered in the stomach. A high degree of suspicion, followed by the necessary immunohistochemistry and molecular studies, is required to make an accurate diagnosis.
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Manohar et al. (2020) conducted a case report in Primary gastric synovial sarcoma (n=1). A rare case of primary gastric synovial sarcoma was identified in a 13-year-old male child, highlighting the need to consider it in the differential diagnosis of gastric spindle cell neoplasms.
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