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November 3, 1999Journal of Biomechanical EngineeringOpen Access

Vortex Shedding as a Mechanism for Free Emboli Formation in Mechanical Heart Valves

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Population

In vitro and numerical simulation model of a bileaflet mechanical heart valve

Design

Preclinical

Authors

DBDanny BluesteinStructural Heart DiseaseEREdmond RambodCalifornia Institute of TechnologyMGMorteza GharibStructural Heart Disease

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Implication

May explain thromboembolic risk in mechanical valves; hypothesis-generating and requires clinical validation.

Structured PICO

P
Population
In vitro and numerical simulation model of a bileaflet mechanical heart valve
I
Intervention
Numerical simulation of unsteady turbulent flow (Wilcox k-omega model) and Digital Particle Image Velocimetry (DPIV)
O
Outcome
Flow patterns, vortex shedding, and particle paths

Vortex shedding in mechanical heart valves entraps platelets exposed to high shear stress, providing a mechanistic explanation for free emboli formation and thromboembolic risk.

Cite This Study

Bluestein et al. (1999) studied this question.

synapsesocial.com/papers/6a788ea7e29fd788c9f80e76https://doi.org/10.1115/1.429634
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relative Blood Damage in the Three Phases of a Prosthetic Heart Valve Flow Cycle1993 · 64 citations
  2. 2On the Hemolytic and Thrombogenic Potential of Occluder Prosthetic Heart Valves From In-Vitro Measurements1981 · 46 citations
  3. 3Studies of Platelet and Fibrinogen Kinetics in Patients with Prosthetic Heart Valves1970 · 332 citations
  4. 4Artificial Heart Valves1990 · 77 citations
  5. 5The effects of elongational stress exposure on the activation and aggregation of blood platelets1991 · 33 citations