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August 2, 2014Pediatric CardiologyOpen Access

Cardiac Function After Repair of Tetralogy of Fallot: How are the Atria Performing? Pilot Study by Cardiac Magnetic Resonance Imaging

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Why the study?

Does repaired Tetralogy of Fallot impair right and left atrial function compared to healthy volunteers?

Population

12 patients after tetralogy of Fallot repair and 10 healthy volunteers

Comparison

Repaired Tetralogy of Fallot evaluated by… vs Healthy volunteers

Design

Cross-sectional

Key result

Patients after tetralogy of Fallot repair showed impaired right atrial reservoir function, with decreased cyclic volume change and atrial filling fraction compared to healthy controls (p<0.01).

Authors

CWChristoph WohlmuthCKChristian J. KellenbergerEVEva M. Voser

Discussion

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Overview

Right atrial impairment may occur after tetralogy of Fallot repair; hypothesis-generating for atrial assessment in congenital cohorts.

Study Design

Type

Observational (n=22)

Structured PICO

Does repaired Tetralogy of Fallot impair right and left atrial function compared to healthy volunteers?

P
Population
12 patients after tetralogy of Fallot repair (mean age 16.7 years) and 10 healthy volunteers evaluated for atrial function using cardiovascular magnetic resonance.
E
Exposure
Repaired Tetralogy of Fallot (TOF) evaluated by cardiovascular magnetic resonance (CMR)
C
Comparator
Healthy volunteers
O
Outcome
Right (RA) and left atrial (LA) functional parameters (volume changes, cyclic volume change, atrial filling fraction, passive/active emptying volume and fraction, conduit volume)surrogate

Main Result

p-value: p=<0.01

Cardiac magnetic resonance imaging demonstrates that right atrial reservoir function is significantly impaired in patients following Tetralogy of Fallot repair.

Cite This Study

Wohlmuth et al. (2014) conducted an observational in Tetralogy of Fallot (n=22). Tetralogy of Fallot repair vs. Healthy volunteers was evaluated on Right atrial cyclic volume change and atrial filling fraction (p=<0.01). Patients after tetralogy of Fallot repair showed impaired right atrial reservoir function, with decreased cyclic volume change and atrial filling fraction compared to healthy controls (p<0.01).

synapsesocial.com/papers/6a78b39dd3a6aa87c6be608ehttps://doi.org/10.1007/s00246-014-0970-y
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