July 29, 2006Nephrology Dialysis TransplantationOpen Access

Predictors of worsening renal function in adult patients with congestive heart failure receiving recombinant human B-type brain natriuretic peptide (nesiritide)

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Why the study?

Does nesiritide increase the risk of acute renal failure in adult patients with congestive heart failure?

Population

219 consecutive adult patients with congestive heart failure

Comparison

Nesiritide vs Not receiving nesiritide

Design

Cohort

Authors

JIJosé IglesiasRutgers, The State University of New Jersey DHD. HomRutgers, The State University of New Jersey MAMarco AntoniottiUniversity of Milano-Bicocca

Discussion

Member takes

Implication

Nesiritide was not associated with acute renal failure in heart failure; hypothesis-generating and requires randomized confirmation before practice change.

Structured PICO

Does nesiritide increase the risk of acute renal failure in adult patients with congestive heart failure?

Population

219 consecutive adult patients with congestive heart failure

Intervention

Nesiritide (recombinant human B-type brain natriuretic peptide)

Comparator

Not receiving nesiritide

Outcome

Development of acute renal failure (ARF), defined as a rise in serum creatinine >0.3 mg/dlsafety

Nesiritide use was not an independent risk factor for acute renal failure in patients with congestive heart failure, although the predictors of renal failure differed based on its use.

Cite This Study

Iglesias et al. (2006) studied this question.

synapsesocial.com/papers/6a78b6486789de8d0af7e90c https://doi.org/10.1093/ndt/gfl428

Topics

HFrEF treatment Heart failure

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Implication

Nesiritide was not associated with acute renal failure in heart failure; hypothesis-generating and requires randomized confirmation before practice change.