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December 6, 2021Frontiers in Cardiovascular MedicineOpen Access

Investigation of the Effects of Home-Based Exercise and Cognitive Training on Cognitive and Physical Functions in Cardiac Patients: The COVEPICARDIO Study Protocol of a Randomized Clinical Trial

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Key result

The COVEPICARDIO trial is a planned randomized clinical trial that will investigate whether combining home-based cognitive training with physical exercise improves cognitive and physical functions more than physical exercise alone in older adults with stable cardiovascular disease.

Why the study?

During the COVID-19 pandemic, confinement increased physical inactivity and sedentary lifestyles in cardiac patients, creating a critical need to evaluate home-based exercise and cognitive training.

Does home-based physical exercise combined with cognitive training improve cognitive performances in adults >50 years old with stable cardiovascular disease compared to home-based physical exercise alone?

Population

122 patients over 50 years old with stable CVD

Comparison

Home-based physical exercise combined with cognitive training vs home-based physical exercise alone

Design

Randomized clinical trial

Follow-up

12 month

Authors

FBFlorent BesnierL'Oréal (France)EDEmma Gabrielle DupuyInsermCGChristine GagnonMontreal Heart Institute

Discussion

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Overview

This study protocol describes a randomized trial to determine if adding cognitive training to home-based physical exercise yields greater cognitive and physical benefits than exercise alone in older adults with stable cardiovascular disease.

Study Design

Type

RCT (n=122)

Blinding

Single-blind

Randomization

1:1

Multicenter

No

Structured PICO

Does home-based physical exercise combined with cognitive training improve cognitive performances in adults >50 years old with stable cardiovascular disease compared to home-based physical exercise alone?

P
Population
122 planned adults aged 50 and older with stable cardiovascular disease, randomized to 6 months of home-based physical exercise alone or combined with cognitive training.
I
Intervention
Home-based physical exercise combined with cognitive training (computerized tasks and strategy-based video capsules) for 6 months, with remote monitoring and coaching.
C
Comparator
Home-based physical exercise alone for 6 months, with remote monitoring and coaching.
O
Outcome
Cognitive performances, including general functioning (Montreal Cognitive Assessment (MoCA) score) and composite z-scores for executive functions, processing speed, and episodic memory.surrogate

This study protocol describes a randomized trial to determine if adding cognitive training to home-based physical exercise yields greater cognitive and physical benefits than exercise alone in older adults with stable cardiovascular disease.

Limitations

  • No control group without intervention due to ethical considerations during the pandemic
  • No precise control of the intensity and duration of the exercise sessions (relies on declarative data)
  • Use of non-exercise prediction equations for cardiorespiratory fitness could lead to significant error in estimated changes
  • Sex was not taken into account in recruitment and randomization processes despite known sex differences in cognition and exercise effects

Cite This Study

Besnier et al. (2021) conducted an RCT in Stable cardiovascular disease (n=122). Home-based physical exercise combined with cognitive training vs. Home-based physical exercise alone was evaluated on Cognitive performances (MoCA and composite z-scores for executive functions, processing speed, and episodic memory). The COVEPICARDIO trial is a planned randomized clinical trial that will investigate whether combining home-based cognitive training with physical exercise improves cognitive and physical functions more than physical exercise alone in older adults with stable cardiovascular disease.

synapsesocial.com/papers/6a78b67bdf493903fd1fc32bhttps://doi.org/10.3389/fcvm.2021.740834
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Home-based physical exercice with additional cognitive training for improving mobility in older adults: a secondary analysis of the COVEPIC randomized controlled trial2026
  2. 2Cardiovascular implications and physical activity in middle-aged and older adults with a history of COVID-19 (CV COVID): a protocol for a randomised controlled trial2023 · 3 citations
  3. 3Effects of 12-Weeks of Home-Based Exercise Training on Physical and Cognitive Function of Older Adults: Randomized Trial Comparing Virtual Versus Minimal Supervision in the Context of the Covid-19 Pandemic in Brazil2024 · 5 citations
  4. 4Effects of Short-Term Exercise and Exercise Training on Cognitive Function Among Patients With Cardiac Disease2007 · 24 citations
  5. 5Exercise and brain health in patients with coronary artery disease: study protocol for the HEART-BRAIN randomized controlled trial2024