October 15, 1997Nucleic Acids ResearchOpen Access

Alternative mRNA splice variants of the rat ClC-2 chloride channel gene are expressed in lung: genomic sequence and organization of ClC-2

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Population

Rat lung tissue / rat ClC-2 gene

Comparison

Genomic sequencing and RT-PCR analysis vs Human ClC-1 gene (hClC-1) genomic map

Design

Preclinical

Authors

SCS ChuCenter for Biologics Evaluation and Research

Discussion

Member takes

Implication

Hypothesis-generating for ClC-2 splice diversity; leaves open translation to human cardiovascular or pulmonary physiology.

Structured PICO

Population

Rat lung tissue / rat ClC-2 gene

Intervention

Genomic sequencing and RT-PCR analysis

Comparator

Human ClC-1 gene (hClC-1) genomic map

Outcome

Identification of mRNA splice variants and genomic organization

The identification of alternative splice variants of the rat ClC-2 chloride channel gene in the lung suggests evolutionary mechanisms of gene duplication and rearrangement.

Cite This Study

S Chu (1997) studied this question.

synapsesocial.com/papers/6a78c436d2fa2470761f9d0e https://doi.org/10.1093/nar/25.20.4153

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Alternative mRNA splice variants of the rat ClC-2 chloride channel gene are expressed in lung: genomic sequence and organization of ClC-2

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Alternative mRNA splice variants of the rat ClC-2 chloride channel gene are expressed in lung: genomic sequence and organization of ClC-2

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider