Key result
Expression of the novel truncated rabbit heart chloride channel rabClC-2 beta induced large Cl- currents that were augmented by PKA activation but unresponsive to cell swelling.
Population
Rabbit heart tissue and Xenopus oocytes used for expression
Comparison
Expression of rabClC-2 beta vs rabClC-2 alpha (ClC-2G)
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether analogous truncated ClC-2 variants regulate human cardiac electrophysiology.
Identification of a novel truncated Cl- channel variant in rabbit heart that is constitutively active and PKA-responsive but insensitive to cell swelling.
Furukawa et al. (1995) studied this question. rabClC-2 beta expression vs. rabClC-2 alpha was evaluated on Cl- currents and responsiveness to extracellular hypotonicity and PKA activation. Expression of the novel truncated rabbit heart chloride channel rabClC-2 beta induced large Cl- currents that were augmented by PKA activation but unresponsive to cell swelling.
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