Key result
Hypertriglyceridemia in type 2 diabetes initiates a sequence of events generating atherogenic lipoproteins and lowering HDL cholesterol, suggesting plasma triglycerides should be kept as low as possible.
Hypertriglyceridemia in type 2 diabetes drives the generation of atherogenic lipoproteins, suggesting plasma triglycerides should be kept as low as possible.
May support triglyceride management in type 2 diabetes; leaves open whether lowering them improves outcomes without randomized confirmation.
The recognition that hypertriglyceridemia is associated with multiple alterations of other lipoproteins that are potentially atherogenic has expanded the picture of diabetic dyslipidemia. Elevation of large VLDL1 particles initiate a sequence of events that results in generation of atherogenic lipoproteins including remnants and small dense LDL. This abnormality is also associated with the lowering of HDL cholesterol. The clinical implication is that the concentration of plasma triglycerides should be maintained as low as possible to avoid these deleterious consequences of hypertriglyceridemia.
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Marja‐Riitta Taskinen (2001) conducted a review in Type 2 diabetes and dyslipidemia. Hypertriglyceridemia was evaluated. Hypertriglyceridemia in type 2 diabetes initiates a sequence of events generating atherogenic lipoproteins and lowering HDL cholesterol, suggesting plasma triglycerides should be kept as low as possible.
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