Key result
A half-dose combination of trandolapril and valsartan significantly lowered MMP-9 levels and suppressed left ventricular remodeling more effectively than trandolapril alone at 12 months in patients with acute myocardial infarction post-PCI.
Why the study?
Does a combination of half-dose trandolapril and valsartan improve left ventricular remodeling and reduce MMP-9 levels compared to regular dose monotherapy in post-AMI patients after primary PCI?
Population
65 adults in Japan with acute myocardial infarction 0-10 days prior who underwent successful primary PCI…
Comparison
Combination of half-regular doses of… vs Regular dose trandolapril or regular dose…
Design
RCT, Minimization method controlling for age, gender, presence of diabetes…
Follow-up
12 months
Authors
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Supports half-dose trandolapril-valsartan over monotherapy post-AMI; extends remodeling evidence with MMP-9 suppression.
RCT (n=65)
Open-label
Minimization method
Yes
Does a combination of half-dose trandolapril and valsartan improve left ventricular remodeling and reduce MMP-9 levels compared to regular dose monotherapy in post-AMI patients after primary PCI?
A half-dose combination of trandolapril and valsartan may suppress left ventricular remodeling and MMP-9 levels more effectively than trandolapril alone in post-AMI patients after primary PCI.
Miyazaki et al. (2010) conducted an RCT in Acute Myocardial Infarction (n=65). Combination of trandolapril and valsartan vs. Trandolapril alone (1-2 mg/day) or Valsartan alone (80-160 mg/day) was evaluated on Left ventricular remodeling (LVEDVI and LVESVI) and MMP-9 levels at 12 months. A half-dose combination of trandolapril and valsartan significantly lowered MMP-9 levels and suppressed left ventricular remodeling more effectively than trandolapril alone at 12 months in patients with acute myocardial infarction post-PCI.
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