Key result
The addition of a copper-depleted diet to 8 weeks of chronic hypoxia did not exacerbate right ventricular hypertrophy (Fulton index 0.40 vs 0.39, p=0.988) or failure in mice compared to hypoxia alone.
Why the study?
Does a copper-depleted diet exacerbate right ventricular remodeling in mice exposed to chronic hypoxia?
Does a copper-depleted diet exacerbate right ventricular remodeling in mice exposed to chronic hypoxia?
Absolute Event Rate: 0.4% vs 0.39%
p-value: p=0.988
In a murine model of pulmonary hypertension, adding a copper-depleted diet to chronic hypoxia does not exacerbate right ventricular remodeling or failure.
Copper depletion does not worsen hypoxic RV remodeling in mice; leaves open any dietary role in human pulmonary hypertension.
BACKGROUND: Pulmonary hypertension and subsequent right ventricular (RV) failure are associated with high morbidity and mortality. Prognosis is determined by occurrence of RV failure. Currently, adequate treatment for RV failure is lacking. Further research into the molecular basis for the development of RV failure as well as the development of better murine models of RV failure are therefore imperative. We hypothesize that adding a low-copper diet to chronic hypoxia in mice reinforces their individual effect and that the combination of mild pulmonary vascular remodeling and capillary rarefaction, induces RV failure. METHODS: Six week old mice were subjected to normoxia (N; 21% O2) or hypoxia (H; 10% O2) during a period of 8 weeks and received either a normal diet (Cu+) or a copper depleted diet (Cu-). Cardiac function was assessed by echocardiography and MRI analysis. RESULTS AND CONCLUSION: Here, we characterized a mouse model of chronic hypoxia combined with a copper depleted diet and demonstrate that eight weeks of chronic hypoxia (10%) is sufficient to induce RV hypertrophy and subsequent RV failure. Addition of a low copper diet to hypoxia did not have any further deleterious effects on right ventricular remodeling.
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Poels et al. (2014) studied Right ventricular remodeling and failure (n=48). Copper-depleted diet vs. Normal diet (both under chronic hypoxia conditions) was evaluated on Right ventricular hypertrophy (Fulton index) (p=0.988). The addition of a copper-depleted diet to 8 weeks of chronic hypoxia did not exacerbate right ventricular hypertrophy (Fulton index 0.40 vs 0.39, p=0.988) or failure in mice compared to hypoxia alone.
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