Population
Preclinical models for nucleic acid delivery (oligonucleotide lipoplexes and intracellular delivery of siRNA)
Design
Preclinical
Authors
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Lipid chain optimization may advance nonviral nucleic acid delivery; leaves open validation in cardiovascular models.
The transfection activity of cationic phosphatidylcholines depends strongly on lipid hydrocarbon chain structure, highlighting the role of non-lamellar lipid mesophases in nucleic acid transport.
Koynova et al. (2014) studied this question.
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