Why the study?
Does oral hydralazine improve haemodynamic parameters more than prazosin in patients with chronic congestive heart failure?
Population
11 patients with chronic congestive heart failure
Comparison
Oral hydralazine vs Oral prazosin hydrochloride (up to 25 mg)
Authors
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May favor hydralazine over prazosin for hemodynamics in severe HF; hypothesis-generating and requires randomized confirmation before practice change.
Does oral hydralazine improve haemodynamic parameters more than prazosin in patients with chronic congestive heart failure?
In patients with severe chronic congestive heart failure, hydralazine provides greater improvement in left ventricular performance (cardiac index and systemic vascular resistance) compared to prazosin.
Chatterjee et al. (1979) studied this question.
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