What question did this study set out to answer?

To assess the acute and 10-week chronic haemodynamic and functional effects of prazosin in patients with severe congestive heart failure.

February 1, 1981HeartOpen Access

Acute and chronic haemodynamic effects of prazosin in left ventricular failure.

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Why the study?

Does prazosin improve haemodynamics and clinical status in patients with chronic congestive heart failure?

Population

11 patients with chronic congestive heart failure, NYHA functional class III and IV.

Design

Case_series

Follow-up

10 weeks

Authors

LSLeon SteinUniversity of Southern California PFPeter R. FosterOchsner Medical Center AFAbraham W. FriedmanSidney & Lois Eskenazi Hospital

Discussion

Member takes

Implication

Prazosin may offer short-term hemodynamic and functional gains in severe HF; leaves open durability, tolerance, and role versus modern therapies in controlled trials.

Key Points

To assess the acute and 10-week chronic haemodynamic and functional effects of prazosin in patients with severe congestive heart failure.
Evaluated 11 patients with chronic congestive heart failure in NYHA functional class III and IV receiving prazosin.
Tracked haemodynamic parameters (mean arterial pressure, left ventricular filling pressure, systemic vascular resistance) acutely and after a 10-week ambulatory course completed by 9 patients.
Acute prazosin administration resulted in haemodynamic improvement in 10 of 11 patients, significantly reducing mean arterial pressure, left ventricular filling pressure, and systemic vascular resistance.
After 10 weeks, all 9 completing patients improved to NYHA functional class II and maintained significant reductions in arterial pressure, ventricular filling pressure, and vascular resistance.
Pharmacodynamic tolerance emerged in 4 of 9 patients (1 complete, 3 partial with attenuated cardiac output response), and 4 patients experienced fluid retention managed by adjusting diuretics or prazosin.

Structured PICO

Does prazosin improve haemodynamics and clinical status in patients with chronic congestive heart failure?

Population

11 patients with chronic congestive heart failure, NYHA functional class III and IV.

Intervention

Prazosin treatment (acute administration and 10-week ambulatory course)

Outcome

Acute and chronic haemodynamic effects (mean arterial pressure, left ventricular filling pressure, systemic vascular resistance) and clinical status (NYHA class)surrogate

Prazosin provides acute and chronic haemodynamic and clinical benefits in severe heart failure, though fluid retention and pharmacodynamic tolerance may occur.

Cite This Study

Stein et al. (1981) studied this question.

synapsesocial.com/papers/6a72a58a8031ec7bb1dd6e51 https://doi.org/10.1136/hrt.45.2.186

Topics

Heart failure HFrEF treatment

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Implication

Prazosin may offer short-term hemodynamic and functional gains in severe HF; leaves open durability, tolerance, and role versus modern therapies in controlled trials.

Acute and chronic haemodynamic effects of prazosin in left ventricular failure.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Acute and chronic haemodynamic effects of prazosin in left ventricular failure.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider