Why the study?
Does repeated administration of prazosin maintain its initial hemodynamic benefits in patients with chronic heart failure?
Does repeated administration of prazosin maintain its initial hemodynamic benefits in patients with chronic heart failure?
The hemodynamic benefits of prazosin in chronic heart failure are transient and attenuate rapidly with repeated dosing, suggesting the need for careful hemodynamic monitoring if long-term therapy is considered.
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May indicate rapid prazosin tolerance in chronic HF; hypothesis-generating and should not yet change practice.
Stephen Arnold (1979) studied this question.
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