March 8, 2017PLoS ONEOpen Access

Acute exhaustive aerobic exercise training impair cardiomyocyte function and calcium handling in Sprague-Dawley rats

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Why the study?

Does acute exhaustive endurance exercise impair cardiomyocyte function and calcium handling in male Sprague-Dawley rats?

Population

Male Sprague-Dawley rats

Comparison

Acute exhaustive endurance exercise consisting… vs Sedentary controls

Design

Preclinical

Authors

KLKristine LjonesNorwegian University of Science and Technology HNHenning O NessNorwegian University of Science and Technology KSKarin Solvang‐GartenNorwegian University of Science and Technology

Discussion

Member takes

Implication

May inform mechanisms of post-exercise RV impairment; hypothesis-generating and leaves open clinical relevance.

Structured PICO

Does acute exhaustive endurance exercise impair cardiomyocyte function and calcium handling in male Sprague-Dawley rats?

Population

Male Sprague-Dawley rats

Intervention

Acute exhaustive endurance exercise consisting of a 120 minutes long forced treadmill run

Comparator

Sedentary controls

Outcome

Contractile function and Ca2+ handling properties in isolated cardiomyocytessurrogate

Acute exhaustive exercise in a rat model impairs cardiomyocyte calcium handling and mitochondrial respiration, providing a cellular mechanism for exercise-induced cardiac fatigue.

Cite This Study

Ljones et al. (2017) studied this question.

synapsesocial.com/papers/6a795c65b9dd6cc1fe0da080 https://doi.org/10.1371/journal.pone.0173449

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Acute exhaustive aerobic exercise training impair cardiomyocyte function and calcium handling in Sprague-Dawley rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Acute exhaustive aerobic exercise training impair cardiomyocyte function and calcium handling in Sprague-Dawley rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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