Why the study?
Antihypertensive treatments may have different effects on central arterial hemodynamics, but the extent of difference between various drugs remains undefined.
Do newer antihypertensive agents (RAS inhibitors and CCBs) improve central arterial hemodynamics compared to older agents (diuretics, β- and α-blockers)?
Population
2,498 patients across 20 randomized controlled trials
Comparison
Newer antihypertensive agents (RAS inhibitors, CCBs) vs older agents (diuretics, β- and α-blockers)
Design
Systematic review and meta-analysis of randomized controlled trials
Authors
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Newer agents may be prioritized for central pressure reduction in hypertension; extends RCT evidence on class-specific central hemodynamic superiority.
Do newer antihypertensive agents (RAS inhibitors and CCBs) improve central arterial hemodynamics compared to older agents (diuretics, β- and α-blockers)?
Newer antihypertensive agents (RAS inhibitors and CCBs) are significantly more efficacious than older agents (diuretics and beta/alpha-blockers) in reducing central hemodynamic parameters.
Cheng et al. (2021) studied this question.
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