Key result
Antihypertensive agents reduced peripheral systolic blood pressure more than central systolic blood pressure (WMD 2.52 mm Hg; 95% CI 1.35-3.69), with beta-blockers being the least beneficial.
Why the study?
Do antihypertensive agents differentially reduce central systolic blood pressure and augmentation index compared to peripheral systolic blood pressure?
Meta-Analysis (n=4,381)
Do antihypertensive agents differentially reduce central systolic blood pressure and augmentation index compared to peripheral systolic blood pressure?
Effect estimate: WMD 2.52 mm Hg (95% CI 1.35 to 3.69)
Beta-blockers are less effective than other antihypertensive classes at reducing central systolic blood pressure and augmentation index, which may explain differences in their impact on cardiovascular outcomes.
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Prioritize non-beta-blockers when central SBP reduction is targeted; confirms class-specific effects in meta-analysis.
McGaughey et al. (2015) reported a meta-analysis. Antihypertensive agents vs. Peripheral systolic blood pressure (pSBP) was evaluated on Difference in reduction between peripheral and central systolic blood pressure (WMD 2.52 mm Hg, 95% CI 1.35 to 3.69). Antihypertensive agents reduced peripheral systolic blood pressure more than central systolic blood pressure (WMD 2.52 mm Hg; 95% CI 1.35-3.69), with beta-blockers being the least beneficial.
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