Why the study?
Do beta-blockers have discordant effects on central versus brachial blood pressure compared to other antihypertensives in patients with uncomplicated hypertension?
Population
Patients with uncomplicated hypertension
Comparison
Beta-blockers (e.g., atenolol) vs Other antihypertensives or placebo
Design
Review
Authors
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Hypothesis-generating for beta-blocker effects on central BP; prospective trials needed before changing hypertension practice.
Do beta-blockers have discordant effects on central versus brachial blood pressure compared to other antihypertensives in patients with uncomplicated hypertension?
Beta-blockers may be less effective in preventing cardiovascular events in uncomplicated hypertension because they lower central aortic blood pressure less effectively than brachial blood pressure.
Epstein et al. (2007) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: