Why the study?
Does PDE5i improve pulmonary hemodynamics and exercise capacity in patients with heart failure?
Does PDE5i improve pulmonary hemodynamics and exercise capacity in patients with heart failure?
PDE5 inhibitors improve pulmonary hemodynamics and exercise capacity in patients with HFrEF, with benefits related to baseline pulmonary arterial pressure, but effects in HFpEF are heterogeneous.
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PDE5i may improve exercise capacity and hemodynamics in selected HFrEF; extends evidence for pulmonary pressure-guided use in future trials.
Hwang et al. (2017) studied this question.
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