Why the study?
Does diltiazem compared to nitroprusside differentially affect left ventricular function in dogs with chronic volume overload?
Population
Awake preinstrumented dogs before and after chronic volume overload produced by an infrarenal aortocaval…
Comparison
Diltiazem administered in equihypotensive… vs Nitroprusside administered in equihypotensive…
Design
Preclinical
Authors
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Diltiazem may depress LV contractility in canine CVO unlike nitroprusside; leaves open translation to human heart failure management.
Does diltiazem compared to nitroprusside differentially affect left ventricular function in dogs with chronic volume overload?
Diltiazem, unlike nitroprusside, depresses left ventricular function in chronic volume overload due to direct negative inotropic effects.
Porter et al. (1983) studied this question.
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