August 10, 2016HypertensionOpen Access

Trajectories of Risk Factors and Risk of New-Onset Atrial Fibrillation in the Framingham Heart Study

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Why the study?

Do longitudinal trajectories of risk factors predict the 15-year risk of incident atrial fibrillation?

Structured PICO

Do longitudinal trajectories of risk factors predict the 15-year risk of incident atrial fibrillation?

Population

4351 Framingham Study participants from the original and offspring cohorts, mean age 50±11 years at baseline examination, 57% women

Intervention

Longitudinal trajectories of AF risk factors (systolic BP, antihypertensive treatment, diastolic BP, smoking, diabetes mellitus, and a composite AF risk score) defined using ≈16 years of data

Comparator

Reference trajectory groups (e.g., normotensive throughout for systolic BP, no treatment throughout for antihypertensive treatment)

Outcome

15-year risk of incident atrial fibrillationhard clinical

Longitudinal trajectories of persistently elevated systolic blood pressure and longer antihypertensive treatment are associated with an increased risk of incident atrial fibrillation.

Discussion

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Implication

AF risk trajectories may refine stratification; hypothesis-generating in observational data, needs prospective validation.

Cite This Study

Rahman et al. (2016) studied this question.

synapsesocial.com/papers/6a796775e357fbdac5890480 https://doi.org/10.1161/hypertensionaha.116.07683

Topics

Hypertension management Atrial fibrillation Persistent AF management

View Full Paper

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Trajectories of Risk Factors and Risk of New-Onset Atrial Fibrillation in the Framingham Heart Study

Structured PICO

Discussion

Implication

Cite This Study

Topics

Trajectories of Risk Factors and Risk of New-Onset Atrial Fibrillation in the Framingham Heart Study

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider