Population
Wild-type and heterozygous methylenetetrahydrofolate reductase knockout mice
Comparison
Angiotensin II infusion vs Vehicle
Design
Preclinical
Authors
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Hypothesis-generating for hyperhomocysteinemia-driven arterial stiffness in mice; human validation required before any clinical inference.
Mild hyperhomocysteinemia increases small artery stiffness and collagen deposition, which is exacerbated by angiotensin II, suggesting a mechanism for its association with cardiovascular disease.
Neves et al. (2004) studied this question.
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