Why the study?
The impact of bariatric surgery on the protein composition of intestinal extracellular vesicles had not previously been investigated.
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Population
Mice
Comparison
Vertical sleeve gastrectomy-treated mice vs controls
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This is the first study that investigates the impact of bariatric surgery on protein composition of intestinal extracellular vesicles. Extracellular vesicle composition is greatly altered after vertical sleeve gastrectomy and may potentially modulate various signaling pathways. In our study, extracellular vesicles from vertical sleeve gastrectomy-treated mice promote bacterial proliferation but exhibit cytotoxic effect on epithelial cells and reduce proliferation of intestinal progenitor cells in mice.
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Myronovych et al. (2020) studied this question.
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