Key result
A baseline resting heart rate below 82 bpm in patients with precapillary pulmonary hypertension was associated with a significantly longer overall event-free survival compared to a heart rate of 82 bpm or higher (2409 vs. 1332 days).
Why the study?
Does a resting heart rate < 82 bpm at diagnosis predict better event-free survival in patients with pulmonary arterial and chronic thromboembolic pulmonary hypertension?
Population
206 patients with precapillary pulmonary hypertension diagnosed as pulmonary arterial or inoperable chronic…
Comparison
Resting heart rate < 82 bpm at diagnosis vs Resting heart rate ≥ 82 bpm at diagnosis
Design
Cohort
Authors
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Supports resting HR <82 bpm for risk stratification in precapillary PH; leaves open whether lowering HR improves outcomes.
Observational (n=206)
No
Does a resting heart rate < 82 bpm at diagnosis predict better event-free survival in patients with pulmonary arterial and chronic thromboembolic pulmonary hypertension?
Absolute Event Rate: 2409% vs 1332%
p-value: p=<0.001
A resting heart rate below 82 bpm at diagnosis is a strong, independent predictor of longer transplant-free survival in patients with PAH and inoperable CTEPH.
Hildenbrand et al. (2012) conducted an observational in Precapillary pulmonary hypertension (PAH and inoperable CTEPH) (n=206). Resting heart rate < 82 bpm vs. Resting heart rate ≥ 82 bpm was evaluated on Overall event-free survival (death or lung transplantation) (p=<0.001). A baseline resting heart rate below 82 bpm in patients with precapillary pulmonary hypertension was associated with a significantly longer overall event-free survival compared to a heart rate of 82 bpm or higher (2409 vs. 1332 days).
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