Key result
Concurrent use of ascorbic acid and warfarin resulted in subtherapeutic INR despite high warfarin doses, with INR rapidly increasing to 15.4 upon ascorbic acid discontinuation.
Why the study?
Does concurrent use of ascorbic acid and warfarin cause warfarin resistance in a patient with acute pulmonary embolism and deep venous thrombosis?
Population
1 65-year-old Caucasian man with chronic cardiac and pulmonary disorders, acute pulmonary embolism, and deep…
Comparison
Concurrent treatment with warfarin and ascorbic… vs Warfarin therapy after discontinuation of…
Design
Case_report
Follow-up
15 days (hospital stay)
Authors
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May signal ascorbic acid-warfarin interaction needing INR vigilance; hypothesis-generating case report leaves causality and generalizability open.
Case Report (n=1)
Does concurrent use of ascorbic acid and warfarin cause warfarin resistance in a patient with acute pulmonary embolism and deep venous thrombosis?
Concurrent use of ascorbic acid may induce warfarin resistance, requiring careful monitoring of INR when starting or stopping the vitamin.
Sattar et al. (2013) conducted a case report in Acute pulmonary embolism and deep venous thrombosis (n=1). Ascorbic acid vs. Discontinuation of ascorbic acid was evaluated on International Normalized Ratio (INR). Concurrent use of ascorbic acid and warfarin resulted in subtherapeutic INR despite high warfarin doses, with INR rapidly increasing to 15.4 upon ascorbic acid discontinuation.
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