Key result
Warfarin therapy at an exceptionally high dose of 120 mg/d was required to reach an INR of 1.8 in a 62-year-old man with unexplained warfarin resistance and no identified genetic mutations.
Why the study?
Adjusting warfarin is challenging due to a narrow therapeutic window, and unexplained resistance requires a stepwise diagnostic evaluation of potential compliance, dietary, pharmacological, and genetic factors.
Population
One 62-year-old man with mechanical prosthetic valves, hypothyroidism, AF, and warfarin resistance
Design
Case report and literature review
Follow-up
6 months and 2 years after discharge
Authors
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Extreme unexplained warfarin resistance warrants clinical vigilance; this case leaves open unidentified mechanisms beyond known variants.
Case Report (n=1)
Highlights a rare case of extreme, unexplained warfarin resistance requiring 120 mg/d without identifiable genetic or acquired causes.
Favaedi et al. (2024) conducted a case report in Warfarin resistance (n=1). Warfarin was evaluated on International normalized ratio (INR). Warfarin therapy at an exceptionally high dose of 120 mg/d was required to reach an INR of 1.8 in a 62-year-old man with unexplained warfarin resistance and no identified genetic mutations.
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