What does this research mean for the field?

Warfarin resistance is a rare condition most commonly caused by noncompliance, drug interactions, or exogenous vitamin K, but can also result from a rare hereditary tissue resistance that must be diagnosed by exclusion. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 12, 1996Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy

Warfarin Resistance: Diagnosis and Therapeutic Alternatives

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Population

Patients with warfarin resistance (based on literature search 1964-1995)

Design

Review

Authors

MHMichelle L. HulseUniversity of the Sciences

Discussion

Member takes

Implication

Clinicians must first exclude common causes of nonresponse; leaves open need for genetic registries to identify additional hereditary mechanisms.

Structured PICO

Population

Patients with warfarin resistance (based on literature search 1964-1995)

True tissue resistance to warfarin is extremely rare; clinicians must first rule out noncompliance, drug interactions, laboratory error, and pharmacokinetic changes.

Cite This Study

Michelle L. Hulse (1996) studied this question.

synapsesocial.com/papers/6a1c197926cb5670aa9d5efe https://doi.org/10.1002/j.1875-9114.1996.tb03026.x

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Implication

Clinicians must first exclude common causes of nonresponse; leaves open need for genetic registries to identify additional hereditary mechanisms.

Warfarin Resistance: Diagnosis and Therapeutic Alternatives

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Warfarin Resistance: Diagnosis and Therapeutic Alternatives

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider