Key result
Hereditary warfarin resistance requires ~4-fold normal plasma levels to achieve adequate anticoagulation.
Why the study?
Hereditary resistance to warfarin is rare and not well characterized, with few families reported.
Population
A 57-year-old black woman and her daughter with hereditary warfarin resistance
Comparison
Warfarin sodium at high dose vs usual warfarin dose
Design
Case report
Authors
Loading...
Hereditary warfarin resistance may require extreme dosing; extends sparse case reports to a third family with pharmacodynamic alteration.
Case Report (n=2)
This case report describes the third known family with hereditary warfarin resistance, demonstrating that the resistance is due to altered pharmacodynamics requiring significantly higher doses for therapeutic anticoagulation.
Barbara M. Alving (1985) conducted a case report in Hereditary Warfarin Resistance (n=2). Warfarin sodium was evaluated on Prothrombin time in a therapeutic range. A 57-year-old woman and her daughter exhibited hereditary warfarin resistance, requiring a daily dosage of 50 mg and plasma levels four times normal to achieve adequate anticoagulation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: