March 1, 1987Vox Sanguinis

Tri(n‐Butyl) Phosphate/Detergent Treatment of Licensed Therapeutic and Experimental Blood Derivatives1

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Population

Licensed therapeutic and experimental blood derivatives and viruses

Design

Preclinical

Authors

CECarol A. EdwardsUniversity of Cambridge MPMarcel P.J. Piët SCSing Chin

Discussion

Member takes

Implication

May support safer virus inactivation in blood derivatives; hypothesis-generating and requires human validation before practice change.

Structured PICO

Population

Licensed therapeutic and experimental blood derivatives (including AHF, factor VII, factor IX, factor X, fibrinogen, factor XIII, fibronectin, anti-HBsAg, anti-HA, haptoglobin, tumor necrosis factor, alpha-interferon, and stroma-free hemoglobin) and viruses (Vesicular stomatitis and Sindbis viruses)

Intervention

Treatment with tri(n-butyl)phosphate (TNBP) and detergent (e.g., 0.3% TNBP and 0.2% sodium cholate)

Outcome

Effect on the structure and function of blood proteins and extent of virus sterilizationsurrogate

TNBP/detergent treatment effectively sterilizes lipid-enveloped viruses in blood protein derivatives without significantly altering their structure or function.

Cite This Study

Edwards et al. (1987) studied this question.

synapsesocial.com/papers/6a79af9e14b028facf0ded3c https://doi.org/10.1111/j.1423-0410.1987.tb02989.x

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Bookmark

Tri(n‐Butyl) Phosphate/Detergent Treatment of Licensed Therapeutic and Experimental Blood Derivatives1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Tri(n‐Butyl) Phosphate/Detergent Treatment of Licensed Therapeutic and Experimental Blood Derivatives1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider