Population
Human antithrombin III concentrate spiked with lipid- and nonlipid-enveloped viruses
Comparison
Liquid iodine with the addition of up to 0.1%… vs Liquid iodine without human albumin
Design
Preclinical
Authors
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May enable iodine-based viral inactivation of AT-III without activity loss; hypothesis-generating for human plasma products.
The addition of human albumin to iodine treatment of AT-III concentrate protects the protein from degradation while allowing effective viral inactivation.
Highsmith et al. (1995) studied this question.
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