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November 14, 1985New England Journal of Medicine

Effects of a Novel Compound (AL 721) on HTLV-III Infectivity in Vitro

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Why the study?

Does AL 721 reduce HTLV-III infectivity in human T-cells in vitro?

Population

Human peripheral-blood lymphocytes or an immortalized helper T-cell line (H9) infected with HTLV-III

Comparison

AL 721 (a lipid compound) vs Control

Design

Preclinical

Follow-up

4 days (in vitro)

Authors

SPSarin PsRGR N GalloSDScheer Di

Discussion

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Implication

AL 721 shows in vitro HTLV-III inhibition; leaves open any clinical role in AIDS pending in vivo trials.

Structured PICO

Does AL 721 reduce HTLV-III infectivity in human T-cells in vitro?

P
Population
Human peripheral-blood lymphocytes or an immortalized helper T-cell line (H9) infected with HTLV-III
I
Intervention
AL 721 (a lipid compound)
C
Comparator
Control (cells incubated with HTLV-III without AL 721)
O
Outcome
Viral infectivity (measured by cell numbers and levels of reverse transcriptase p15 and p24)surrogate

AL 721 demonstrates in vitro inhibition of HTLV-III infectivity, suggesting potential as a novel therapeutic candidate for AIDS.

Cite This Study

Ps et al. (1985) studied this question.

synapsesocial.com/papers/6a79af9e14b028facf0ded3dhttps://doi.org/10.1056/nejm198511143132011
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)1983 · 7,000 citations
  2. 2Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDS1984 · 3,545 citations
  3. 3Interaction of vesicular stomatitis virus with lipid vesicles: depletion of cholesterol and effect on virion membrane fluidity and infectivity1978 · 45 citations