Key result
Curcumin combined with enalapril significantly improved left ventricular fractional shortening to 34.4% compared to 29.0% with enalapril alone and 19.7% with vehicle in post-myocardial infarction rats.
Why the study?
Does the combination of curcumin and enalapril improve left ventricular systolic function in a rat model of post-myocardial infarction heart failure?
Does the combination of curcumin and enalapril improve left ventricular systolic function in a rat model of post-myocardial infarction heart failure?
Absolute Event Rate: 34.4% vs 29%
p-value: p=<0.05
The combination of the p300-specific HAT inhibitor curcumin and enalapril synergistically improves left ventricular systolic function and attenuates cardiomyocyte hypertrophy in a rat model of post-MI heart failure.
No takes yet. Share an insight, caveat, or question.
Does not support clinical use of curcumin post-MI; leaves open translation of LV function benefit to human trials.
Sunagawa et al. (2011) studied Myocardial Infarction / Heart Failure (n=40). Curcumin in addition to enalapril vs. Enalapril alone (10 mg/kg/day) or vehicle was evaluated on Left ventricular fractional shortening (LVFS) (p=<0.05). Curcumin combined with enalapril significantly improved left ventricular fractional shortening to 34.4% compared to 29.0% with enalapril alone and 19.7% with vehicle in post-myocardial infarction rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: