Key result
ABHD6 expression in NSCLC was significantly associated with advanced TNM stage (HR 1.382; P=0.004) and had a negative impact on overall survival (P=0.001).
Why the study?
Elevated monoacylglycerol hydrolysis correlates with malignancy in various cancers, but evidence was absent for the relationship between MAG lipolysis and NSCLC.
Observational
Hazard Ratio: 1.382
p-value: p=0.004
ABHD6 acts as an oncogene in NSCLC by promoting monoacylglycerol lipolysis, suggesting it as a potential therapeutic target.
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MAGL/ABHD activity may promote NSCLC progression; leaves open whether targeting MAG hydrolysis improves outcomes.
Tang et al. (2020) conducted an observational in Non-Small Cell Lung Cancer (NSCLC). ABHD6 expression vs. Lower or absent ABHD6 expression was evaluated on Advanced tumor node metastasis (TNM) stage (HR 1.382, p=0.004). ABHD6 expression in NSCLC was significantly associated with advanced TNM stage (HR 1.382; P=0.004) and had a negative impact on overall survival (P=0.001).
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