Why the study?
Does FFP photochemically treated with amotosalen and UV light provide equivalent FVII kinetics compared to standard FFP in healthy volunteers anticoagulated with warfarin?
Does FFP photochemically treated with amotosalen and UV light provide equivalent FVII kinetics compared to standard FFP in healthy volunteers anticoagulated with warfarin?
Photochemically treated FFP with amotosalen and UV light provides an equivalent in vivo coagulation response to standard FFP in warfarin-treated healthy volunteers.
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May support treated FFP as alternative in warfarin reversal; leaves open translation to clinical hemostasis in bleeding patients.
Hambleton et al. (2002) studied this question.
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