Key result
Early administration of SGLT2 inhibitors in patients with acute decompensated heart failure improves clinical outcomes, enhances decongestion, and reduces hospital readmissions.
Why the study?
Acute decompensated heart failure carries a poor prognosis and low survival, prompting evaluation of the evidence for early administration of SGLT2 inhibitors.
Does early administration of SGLT2 inhibitors improve renal function in patients with acute decompensated heart failure?
Systematic Review
Does early administration of SGLT2 inhibitors improve renal function in patients with acute decompensated heart failure?
This systematic review aims to synthesize evidence on the effects of early SGLT2 inhibitor administration on renal function in acute decompensated heart failure.
Should not yet change practice in acute decompensated heart failure; leaves open need for dedicated randomized trials.
The current worldwide prevalence of heart failure is growing, while its combination with cardiovascular and other conditions determines a poor prognosis in these patients. Furthermore, acute decompensated heart failure is associated with a low survival rate mostly caused by target organ damage. The effects of early administration of SGLT2 inhibitors on renal function in patients with acute decompensated heart failure are being studied to determine the possibility of improving response to treatment, as well as partial or complete recovery of renal function. The goal of the review was to synthesize currently available evidence for the use of SGLT2 inhibitors in patients with acute decompensated heart failure. A systematic search for studies published from 2018 to 2021 and their analysis was carried out in the following databases: Web of Science, Scopus, PubMed/MEDLINE.
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Lapteva et al. (2022) conducted a systematic review in Acute decompensated heart failure. SGLT2 inhibitors vs. Placebo or standard therapy was evaluated. Early administration of SGLT2 inhibitors in patients with acute decompensated heart failure improves clinical outcomes, enhances decongestion, and reduces hospital readmissions.
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