Why the study?
Does in vitro renal metabolism of angiotensin-(1-7) receptor ligands alter their binding affinity to angiotensin receptor subtypes in rat and bovine tissue models?
Population
Rat liver and adrenal medulla membranes, bovine kidney epithelial cell membranes, and rat cortical tissue…
Comparison
In vitro renal metabolism of angiotensin… vs Unmetabolized peptides
Design
Preclinical
Authors
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Does not yet alter clinical use of angiotensin ligands; leaves open whether AT4 binding contributes to renal actions in vivo.
Does in vitro renal metabolism of angiotensin-(1-7) receptor ligands alter their binding affinity to angiotensin receptor subtypes in rat and bovine tissue models?
Renal metabolism of angiotensin-(1-7) receptor ligands generates products with high affinity for the AT4 receptor, potentially contributing to their biologic actions in the kidney.
Rajash K. Handa (2000) studied this question.
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