April 1, 1996Hypertension

Evidence for a Physiological Role of Angiotensin-(1-7) in the Control of Hydroelectrolyte Balance

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Why the study?

Does Angiotensin-(1-7) act as an endogenous osmoregulatory peptide in rats?

Population

Rats (water-loaded) and in vitro inner medullary collecting ducts

Comparison

Angiotensin- [Ang-] and its selective antagonist… vs Vehicle

Design

Preclinical

Authors

RSRobson A.S. SantosGeneral Cardiology ASAna Cristina Simões e SilvaUniversidade Federal de Juiz de Fora AMAntônio J. MagaldiUniversidade de São Paulo

Discussion

Member takes

Implication

No direct clinical implications; extends evidence for Ang-(1-7) in rat water balance but leaves human relevance open.

Structured PICO

Does Angiotensin-(1-7) act as an endogenous osmoregulatory peptide in rats?

Population

Rats (water-loaded) and in vitro inner medullary collecting ducts

Intervention

Angiotensin-(1-7) [Ang-(1-7)] and its selective antagonist [D-Ala7]Ang-(1-7) (A-779)

Comparator

Vehicle

Outcome

Renal function parameters including urine volume, creatinine clearance, and urine osmolalitysurrogate

Endogenous Ang-(1-7) participates in the control of hydroelectrolyte balance by influencing water excretion via specific receptors.

Cite This Study

Santos et al. (1996) studied this question.

synapsesocial.com/papers/6a7073e36ceb2bbd16dfe52c https://doi.org/10.1161/01.hyp.27.4.875

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Evidence for a Physiological Role of Angiotensin-(1-7) in the Control of Hydroelectrolyte Balance

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence for a Physiological Role of Angiotensin-(1-7) in the Control of Hydroelectrolyte Balance

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider