March 1, 1981Infection and ImmunityOpen Access

Lysis of herpes simplex virus-infected cells early in the infectious cycle by human antiviral antibody and complement

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Population

Chang liver cells and human embryonic lung fibroblasts infected with type 1 herpes simplex virus

Comparison

Human antiviral antibody and complement vs Guinea pig serum as complement source; varying…

Design

Preclinical

Authors

TCTheresa L. CromeansCDC Foundation SSSteven L. ShoreUnited States Public Health Service

Discussion

Member takes

Implication

Early antibody-complement lysis may limit HSV spread in culture; leaves open in vivo relevance and therapeutic translation.

Structured PICO

Population

Chang liver (CL) cells and human embryonic lung fibroblasts (MRC-5) infected with type 1 herpes simplex virus (HSV)

Intervention

Human antiviral antibody and complement (1:2 dilution of fresh HSV antibody-positive human serum)

Comparator

Guinea pig serum as complement source; varying experimental conditions (suspension vs monolayer, cell density)

Outcome

Time postinfection at which cells became susceptible to lysis, measured by 51Cr release assaysurrogate

HSV-infected tissue culture cells can be lysed by antiviral antibody and complement early in the infectious cycle before the initial production of progeny virus particles.

Cite This Study

Cromeans et al. (1981) studied this question.

synapsesocial.com/papers/6a79d4c28d250a4360f3c458 https://doi.org/10.1128/iai.31.3.1054-1061.1981

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Lysis of herpes simplex virus-infected cells early in the infectious cycle by human antiviral antibody and complement

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Lysis of herpes simplex virus-infected cells early in the infectious cycle by human antiviral antibody and complement

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider