Why the study?
Does ET(A) receptor blockade with ABT-627 modulate cardiac natriuretic peptide gene expression in rats with renovascular hypertension?
Population
Male Sprague-Dawley rats weighing 100-125 g with induced two kidney-one clip Goldblatt renovascular…
Comparison
ABT-627 (ET receptor antagonist) 10 mg/kg per… vs Sham operated rats and untreated 2K-1C rats
Design
Preclinical
Follow-up
6 weeks
Authors
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Hypothesis-generating in renovascular hypertension models; confirms ET-1 role in ventricular NP expression but requires human trials.
Does ET(A) receptor blockade with ABT-627 modulate cardiac natriuretic peptide gene expression in rats with renovascular hypertension?
ET-1 participates in the increased expression of ventricular natriuretic peptides in renovascular hypertension, as demonstrated by the effects of ET(A) blockade in a rat model.
Liliana G. Bianciotti (2001) studied this question.
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