Why the study?
Does selective ET(A) receptor blockade with ABT-627 affect natriuretic peptide gene expression in DOCA-salt hypertensive rats?
Population
Normal controls and rats with deoxycorticosterone acetate (DOCA)-salt hypertension
Comparison
Chronic administration of ABT-627 (selective ET… vs Untreated DOCA-salt hypertensive rats and normal…
Design
Preclinical
Authors
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ET(A) blockade may differentially modulate ventricular NP expression in experimental hypertension; leaves open translation to human disease and clinical use.
Does selective ET(A) receptor blockade with ABT-627 affect natriuretic peptide gene expression in DOCA-salt hypertensive rats?
Ventricular, but not atrial, natriuretic peptide production is regulated by ET-1 in vivo, suggesting differential sensitivity to the endocrine environment.
Liliana G. Bianciotti (2000) studied this question.
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