Key result
Heart failure was associated with a significant decrease in network centrality in the precuneus, correlating positively with left ventricular ejection fraction and negatively with NT-proBNP.
Why the study?
Little is known about heart failure-associated changes in specific brain functions, and a satisfactory pathophysiological link between heart failure and cognitive decline is missing.
Comparison
Patients with vs without heart failure (and with vs without coronary artery disease)
Design
Cross-sectional functional magnetic resonance imaging study
Authors
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Functional connectivity alterations in HF may underlie cognitive decline; leaves open causal links and clinical relevance.
Observational (n=80)
Heart failure is associated with reduced functional brain connectivity in the precuneus, correlating with disease severity and cognitive decline, suggesting shared pathophysiological pathways with neurodegeneration.
Mueller et al. (2023) conducted an observational in Heart failure (n=80). Heart failure vs. Without heart failure was evaluated on Functional brain connectivity (network centrality) and cognitive performance. Heart failure was associated with a significant decrease in network centrality in the precuneus, correlating positively with left ventricular ejection fraction and negatively with NT-proBNP.
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