Key result
Decreased cardiac ejection fraction and increased NT-proBNP were significantly correlated with diminished gray matter density in the frontomedian cortex, hippocampus, and precuneus.
Why the study?
Heart failure causes neurological symptoms and regional gray matter decrease, but the implications for brain structure and the underlying mechanisms leading to observed brain changes remain unclear.
Population
80 patients of the Leipzig Heart Center
Comparison
Correlation between HF biomarkers and brain gray matter density
Design
Case-control study
Authors
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HF-associated gray matter loss may flag cognitive vulnerability; leaves open causal roles of biomarkers in larger prospective cohorts.
Case-Control (n=80)
No
Heart failure severity, as indicated by reduced ejection fraction and elevated NT-proBNP, is associated with decreased gray matter density in brain regions linked to cognition and dementia.
Mueller et al. (2020) conducted a case-control in Heart failure (n=80). Heart failure biomarkers (ejection fraction and NT-proBNP) was evaluated on Correlation between heart failure biomarkers and brain gray matter density (GMD). Decreased cardiac ejection fraction and increased NT-proBNP were significantly correlated with diminished gray matter density in the frontomedian cortex, hippocampus, and precuneus.
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