August 1, 2003Journal of Applied Physiology
Regional brain gray matter loss in heart failure
Why the study?
Do heart failure patients exhibit regional brain gray matter loss compared to healthy controls?
Population
9 heart failure patients and 27 healthy controls
Comparison
T1-weighted magnetic resonance imaging and… vs Healthy controls
Design
Case-control
Authors
Discussion
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Member takes
Implication
May link gray matter loss to autonomic dysregulation in HF; leaves open causality and needs longitudinal confirmation.
Structured PICO
Do heart failure patients exhibit regional brain gray matter loss compared to healthy controls?
P
Population
9 heart failure patients (mean age 51 +/- 10 yr; LVEF 0.27 +/- 0.06; 6 men) and 27 healthy controls (mean age 46 +/- 12 yr; 22 men)
I
Intervention
T1-weighted magnetic resonance imaging and voxel-based morphometry
C
Comparator
Healthy controls
O
Outcome
Regional gray matter volumessurrogate
Heart failure patients exhibit significant regional gray matter loss in brain areas associated with autonomic and respiratory control, suggesting a structural neural basis for dysregulation in HF.
Cite This Study
Woo et al. (2003) studied this question.