Why the study?
Do patients with heart failure have reduced global and regional putamen volumes compared to control subjects?
Population
48 subjects, comprising 16 patients with heart failure and 32 control subjects.
Design
Case-control
Authors
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May explain cognitive-motor deficits in HF; hypothesis-generating and requires longitudinal confirmation before any clinical inference.
Do patients with heart failure have reduced global and regional putamen volumes compared to control subjects?
Heart failure is associated with significant global and localized volume reductions in the putamen, which may contribute to the cognitive and motor deficits observed in these patients.
Kumar et al. (2011) studied this question.
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