Brain structural changes associated with aberrant functional responses to the Valsalva maneuver in heart failure
Why the study?
Are brain structural changes associated with aberrant functional neural responses to the Valsalva maneuver in patients with heart failure compared to controls?
Population
64 subjects; a subsample of 19 heart failure and 24 control subjects underwent diffusion tensor imaging
Comparison
Valsalva maneuver evaluated with blood oxygen… vs Control subjects
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Suggests brain injury may underlie autonomic deficits in HF; leaves open direct structure-function links in regulatory areas.
Structured PICO
Are brain structural changes associated with aberrant functional neural responses to the Valsalva maneuver in patients with heart failure compared to controls?
P
Population
64 subjects (29 heart failure patients and 35 control subjects); a subsample of 19 heart failure and 24 control subjects underwent diffusion tensor imaging
I
Intervention
Valsalva maneuver evaluated with blood oxygen level-dependent functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI)
C
Comparator
Control subjects
O
Outcome
Neural responses to the Valsalva maneuver (fMRI) and brain structural changes (diffusion tensor imaging-based mean diffusivity)surrogate
Heart failure is associated with structural and functional brain alterations in autonomic regulatory areas, which may explain the autonomic deficits seen in these patients.
Cite This Study
Song et al. (2018) studied this question.