Why the study?
Does enalapril or nifedipine attenuate the blood pressure and renal responses to endothelin-1 infusion in healthy volunteers?
Population
6 healthy volunteers
Comparison
Oral enalapril or nifedipine prior to… vs Endothelin-1 infusion alone
Design
Other
Follow-up
90 minutes
Authors
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Nifedipine may better preserve renal hemodynamics against endothelin than enalapril; leaves open clinical relevance in patients.
Does enalapril or nifedipine attenuate the blood pressure and renal responses to endothelin-1 infusion in healthy volunteers?
Nifedipine is more effective than enalapril in antagonizing the renal vasoconstrictive effects of endothelin in healthy humans.
Kaasjager et al. (1995) studied this question.
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