Why the study?
Does nifedipine GITS compared to enalapril improve ambulatory blood pressure control and reduce proteinuria in elderly nondiabetic hypertensive patients?
Population
46 elderly nondiabetic hypertensive patients
Comparison
Sustained-release nifedipine 30-120 mg/day vs Enalapril 5-30 mg/day
Design
RCT, Sequential randomized, Double-blind
Follow-up
16 to 18 weeks
Authors
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Supports nifedipine GITS for superior 24-hour BP control in elderly hypertensives; extends RCT evidence of equivalent proteinuria reduction versus enalapril.
Does nifedipine GITS compared to enalapril improve ambulatory blood pressure control and reduce proteinuria in elderly nondiabetic hypertensive patients?
Nifedipine GITS and enalapril are equally effective in reducing proteinuria in elderly nondiabetic hypertensives, though nifedipine GITS provides superior 24-hour ambulatory blood pressure control.
DeQuattro et al. (2008) studied this question.
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